Alternative Carrier Ingredients for Cream Formulations

Based on your situation and the information available, here are some alternative carrier ingredients that are commonly used in cream formulations and may be suitable for your product:

It appears the FDA's concern with Ethoxydiglycol in your cream formulation might be related to its typical use profile, which often includes spray applications. For a cream base, you need carriers or solvents that are compatible with the cream's texture and application method.

Here are a few options that function as solvents or emollients and are suitable for creams:

• Butylene Glycol: This is a widely used solvent in cosmetic formulations, including serums, lotions, and creams. It is known for being gentler and less irritating than Propylene Glycol and has a lighter texture. It can be mixed into the formula at various stages.
• Propylene Carbonate: This ingredient is commonly used as a solvent or emollient in skin care products. It is lightweight and can help improve the spreadability and lightness of a formula. It dissolves in water.
• Sorbitol Solution 70%: While primarily a humectant, Sorbitol can also function as a solvent in cosmetic formulations.
• Isopropylidenglycerin (Solketal): This is another solvent that can be used in various product types and dissolves in water.

Butylene Glycol and Propylene Carbonate are often preferred in cream formulations for their compatibility and ability to enhance texture and spreadability, in addition to their solvent properties.

Consider testing these alternatives in your cream base to see which provides the desired performance and texture for your specific formulation before submitting for notification again.