Betaine Salicylate Solubility Issue in Acne Cream Formulation
Question
In a cream formulation for acne-prone skin, I am using Betaine Salicylate 2.5% mixed with Water 20% and Triethanolamine 0.1% to adjust the pH to 3.8-4.2. Even after stirring and homogenizing with a Homo mixer, the Betaine Salicylate is not dissolving and is settling at the bottom. How should I properly mix it to achieve dissolution?
Answer
How to Dissolve SalicSoft® (Betaine Salicylate)
Based on the product information for SalicSoft® (Betaine Salicylate), it is soluble in water specifically when the pH is within the range of 3.8 to 4.2. To achieve this solubility, you need to use Triethanolamine to adjust the pH.
The issue you are encountering, where the SalicSoft® is settling at the bottom, is likely because the pH of your mixture is not yet within the required 3.8-4.2 range, even after adding 0.1% Triethanolamine. The amount of Triethanolamine needed can vary depending on the overall formulation.
Here is the correct method to dissolve SalicSoft® in water:
- Mix the SalicSoft® (Betaine Salicylate) with water. At this stage, it will typically not be fully soluble.
- Begin adding Triethanolamine gradually, a little at a time.
- After each small addition of Triethanolamine, stir the mixture well and measure the pH value.
- Continue adding Triethanolamine and checking the pH until the pH of the mixture falls within the range of 3.8 to 4.2.
- Once the pH is correctly adjusted to 3.8-4.2, stir or homogenize the mixture. The SalicSoft® should then become fully soluble and the solution should be clear.
Using a fixed percentage of Triethanolamine like 0.1% may not be sufficient to reach the required pH for dissolution. The key is to adjust the pH into the 3.8-4.2 range using Triethanolamine, adding just enough to get there.
Related Products Mentioned
Triethanolamine 99%