Anti-Aging Ingredients for Combination, Dehydrated, Sebderm Skin with Wrinkles and Sagging

Thank you for reaching out with your questions about formulating your own cream. It's understandable to have questions when you're new to this!

Regarding the difference between the "base" and "tester" versions of Double Hyaluronic gel, the available information focuses on the properties of the active ingredients rather than specific product versions. It's best to check the product details directly on the website or contact the vendor for clarification on the specific versions you are interested in.

Regarding your questions about anti-aging ingredients and mixing them with Double Hyaluronic gel, based on your skin concerns (43 years old, combination, dehydrated, sebderm, deep wrinkles, sagging) and the ingredients you are considering, here is some information:

For your skin concerns, choosing anti-aging ingredients should focus on efficacy for wrinkles and sagging while being gentle on sebderm-prone skin.

Among the ingredients you mentioned:

• Argireline (Acetyl Hexapeptide-8): This ingredient helps reduce muscle contractions that cause dynamic wrinkles, particularly on the forehead and around the eyes. It is suitable for existing deep wrinkles.
• Matrixyl 3000 (Pal-GHK, Pal-GQPR): This peptide stimulates collagen synthesis and other important skin components, helping to reduce wrinkles, improve elasticity, and firm the skin. It is suitable for addressing sagging and overall wrinkles.

Information from the manufacturer suggests that Argireline and Matrixyl 3000 can be used together. Argireline targets wrinkles caused by muscle movement, while Matrixyl 3000 works on overall skin structure, offering a complementary anti-aging effect.

Regarding Gladback™ and DermaE Bitartrate59, specific product information matching these exact names was not found in the available data, so I cannot provide details on their specific properties or usage.

Therefore, based on the ingredients you mentioned and the available information, Argireline and Matrixyl 3000 are relevant options for addressing both deep wrinkles and sagging skin concerns.

Mixing with Double Hyaluronic gel:

Both Argireline (Acetyl Hexapeptide-8) and Matrixyl 3000 (Pal-GHK, Pal-GQPR) are water-soluble according to the product information. They are recommended to be added in the final step of formulation, with the base temperature below 40°C. Double Hyaluronic gel, being a water-based gel, is compatible with these ingredients. You can directly mix both Argireline and Matrixyl 3000 into your Double Hyaluronic gel base.

Regarding your concern about ingredients like DermaE Bitartrate59 needing dissolution and pH adjustment (for which specific data was not available), it is true that some active ingredients require specific preparation steps, such as dissolving in a suitable solvent or adjusting the pH for stability and efficacy. If you choose an ingredient with such requirements, you would need to follow its usage instructions carefully. However, for water-soluble ingredients like Argireline and Matrixyl 3000, mixing into a water-based gel is simpler.

Additional Recommendations:

• Given your sebderm-prone skin, which can be sensitive, it's advisable to start with lower concentrations within the recommended usage range for each ingredient and perform a patch test on a small area of skin before applying to your entire face.
• Ensure all equipment and containers used for mixing are clean to prevent contamination.
• Store the finished product appropriately, following the storage recommendations for the individual active ingredients (e.g., refrigeration for Argireline and Matrixyl 3000).

In summary, if you choose to use Argireline and Matrixyl 3000, you can mix them directly into your Double Hyaluronic gel. These two ingredients offer benefits for both wrinkles and sagging concerns.