Combining Tranexamic Acid and Azelaic Acid: Formulation & Penetration
Asked by: jn_andy
On: January 07, 2016
Product Type:
Cosmetics
Question
I want to combine Tranexamic Acid and Azelaic Acid in a formulation.
- Can they be used together?
- What concentration is recommended when used together, considering potential irritation?
- What is the typical pH of this combination, and how can it be adjusted?
- To improve skin penetration, which penetration enhancer is better for these water-soluble ingredients: PE-1 Aqua or Pentylene Glycol?
Answer
Based on the provided conversation:
- Yes, Tranexamic Acid and Azelaic Acid can technically be used together.
- When combining them, it is recommended to significantly reduce the concentration of both ingredients due to their potential to cause skin irritation.
- The resulting mixture will typically have a neutral pH, around 6.5-7.5. You can adjust the pH slightly lower using mild acids like Glycolic Acid or Lactic Acid (AHAs) to make the formulation gentler on the skin.
- To improve the penetration of these water-soluble ingredients into the skin, adding a penetration enhancer like PE-1 Aqua (around 3%) is recommended. Pentylene Glycol is mentioned but is less effective for water-soluble ingredients compared to PE-1 Aqua.
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