Combining Tranexamic Acid, Safe-B3™, and Phenylethyl Resorcinol (Sym-White™) in Formulations

Yes, Tranexamic Acid, Safe-B3™ (Niacinamide), and Phenylethyl Resorcinol (e.q. SymWhite 377) can generally be combined in a cosmetic formulation. These ingredients work through different mechanisms to target skin brightening and improve overall skin tone, making them potentially synergistic.

• Tranexamic Acid: Primarily targets melasma and dark spots by reducing melanin formation.
• Safe-B3™ (Niacinamide): Improves skin barrier function, reduces hyperpigmentation and redness, controls oil, and offers anti-aging benefits.
• Phenylethyl Resorcinol (e.q. SymWhite 377): A potent tyrosinase inhibitor that effectively brightens skin and acts as an antioxidant.

When formulating with these ingredients, consider the following:

• pH Level: Phenylethyl Resorcinol is most stable at a pH of 4-5. Niacinamide is best at pH 4-7, and Tranexamic Acid is stable from pH 3-8. Aiming for a pH in the range of 4-5 would be suitable for combining all three.
• Mixing Method: Tranexamic Acid and Niacinamide are water-soluble and can be mixed in the water phase. Phenylethyl Resorcinol is oil-soluble and typically added in the final step of the formulation, often with gentle heat (not exceeding 50°C) to help it dissolve into the cream base. The formula must contain an oil phase for Phenylethyl Resorcinol to dissolve properly.
• Compatibility: Avoid ingredients like Amino Acids, Urea, certain proteins, Carbomer, Carbopol, and PEG-400 when formulating with Phenylethyl Resorcinol, as they may cause stability issues (yellowing or separation). Test compatibility with any fragrance used.
• Storage: Store the finished product protected from light and air to maintain stability.

Combining these ingredients allows for a multi-targeted approach to addressing hyperpigmentation, uneven skin tone, and overall skin health.