Comparing Liquid vs. Powder Hyaluronic Acid for Gel Formulation and Solubility
Question
I am trying to formulate a gel using Hyaluronic Acid. I previously used the powder form but found it very difficult to dissolve.
I am now considering using Double Hyaluron Liquid instead. The product description states it is a blend of 2.5% Nano Molecule and 2.5% Standard Molecule.
If I use the liquid form, will I be able to achieve the same gel-like viscosity as when using the powder form, assuming the final concentration of active Hyaluronic Acid in the formula is the same?
Answer
Understanding Liquid vs. Powder Hyaluronic Acid for Formulations
Regarding your question about using liquid hyaluronic acid instead of powder and whether it will achieve a similar gel-like viscosity, here is an explanation:
The liquid form you mentioned, likely Double Hyaluron Liquid, is a pre-dissolved solution. According to the product description, it contains a total of 5% Hyaluronic Acid, specifically a blend of 2.5% Nano Molecule and 2.5% Standard Molecule.
The viscosity or gel-like texture of your final formulation depends primarily on the total concentration of active Hyaluronic Acid in the formula, particularly the higher molecular weight types like Hyaluronic Acid (Standard Molecule) and Hyaluronic Acid (Large Molecule). Lower molecular weight types like Hyaluronic Acid (Small Molecule) and Hyaluronic Acid (Nano Molecule, 800daltons) are absorbed deeper into the skin for hydration but do not contribute significantly to gelling.
Since Double Hyaluron Liquid contains the Standard Molecule type (2.5% concentration in the liquid), it can contribute to the gel texture of your formulation. If you use an amount of Double Hyaluron Liquid that results in the same final concentration of active Hyaluronic Acid (specifically the Standard or higher molecular weight components) in your total formula as when you used the powder, the resulting viscosity should be similar.
The main benefit of using the liquid form is its ease of use. As you experienced, dissolving the powder form can be difficult and time-consuming, often requiring specific mixing methods or long hydration periods. The liquid form dissolves immediately in water-based formulas.
To achieve a similar viscosity to your previous attempts with powder, you need to calculate how much Double Hyaluron Liquid (which is a 5% active HA solution) to add to your formula to reach your desired final concentration of active HA. For example, if you wanted a 0.1% final concentration of active HA in your formula using powder, you would need to add 2% of the 5% Double Hyaluron Liquid (because 2% of 5% is 0.1%).
In summary, using the liquid form can achieve a similar gel texture if the final concentration of active HA (especially the Standard molecule component) is the same as when using the powder, and it offers the significant advantage of easier dissolution.
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