Compatibility of Cetrimonium Chloride and SLES

Based on the product information for Cetrimonium Chloride and general formulation principles, Cetrimonium Chloride, which is a cationic surfactant, is generally not compatible with anionic surfactants like Sodium Laureth Sulfate (SLES).

Mixing cationic and anionic surfactants can lead to interactions between their opposite charges, potentially causing precipitation, cloudiness, or a reduction in the performance of both ingredients.

The product description for Cetrimonium Chloride specifically advises against using it with anionic surfactants.

While it might be possible to carefully combine them by adding the anionic surfactant first and then slowly incorporating the Cetrimonium Chloride, it is generally recommended to avoid this combination if possible to ensure stability and optimal performance of the formulation.

A better approach when using Cetrimonium Chloride is to pair it with amphoteric or non-ionic surfactants, which are compatible with cationic ingredients.