Compatibility of Eye Preserved™ with Hyaluronic Acid and Allantoin

Regarding your question about mixing Eye Preserved™ (Polyaminopropyl Biguanide) with ingredients like Hyaluronic Acid (found in bamboo mushroom jelly and Double Hyaluron Liquid) and Allantoin:

Eye Preserved™ is a cationic ingredient, meaning it carries a positive charge. Hyaluronic Acid, on the other hand, is anionic, carrying a negative charge. When cationic and anionic ingredients are mixed, they tend to interact and neutralize each other. This incompatibility is explicitly stated in the product information for Eye Preserved™, which lists "Hyaluronic Acid all kinds" as incompatible substances.

Mixing Eye Preserved™ with ingredients containing Hyaluronic Acid is generally not possible because this interaction can lead to:

• Precipitation or cloudiness in the formula.
• Loss of efficacy for both the preservative (Eye Preserved™) and the Hyaluronic Acid.
• Changes in the texture or viscosity of the product, such as thinning of gels.

While there was a suggestion about potentially testing with very small molecular weight Hyaluronic Acid, the product documentation indicates incompatibility with all types. Therefore, attempting this mixture is risky and not recommended for a stable or effective formulation. If you choose to experiment, thorough stability and challenge testing would be absolutely necessary.

Regarding Allantoin, based on the available information, Allantoin does not appear to have an incompatibility issue with cationic ingredients like Eye Preserved™. You should be able to mix Eye Preserved™ with Allantoin without encountering the same problems as with Hyaluronic Acid.

In summary, mixing Eye Preserved™ with the Hyaluronic Acid component of the bamboo mushroom jelly is likely to cause significant compatibility issues. Mixing with Allantoin, however, should be acceptable.