Compatibility of Phospholipid, 1,2-Hexanediol, and DMI in Formulation

Yes, Phospholipid, 1,2-Hexanediol, and Dimethyl Isosorbide (DMI) can be mixed together in the same formulation.

These three ingredients are commonly used in cosmetic formulations, often for their properties as penetration enhancers, helping other active ingredients absorb better into the skin.

• Phospholipid can act as a natural emulsifier (though some forms are better as co-emulsifiers) and helps form structures like liposomes, which can improve ingredient delivery and provide moisturizing benefits.
• 1,2-Hexanediol functions as a solvent, humectant (attracts water), preservative booster, and also a penetration enhancer.
• Dimethyl Isosorbide (DMI) is a highly effective solvent and penetration enhancer, particularly useful for delivering water-soluble active ingredients.

Formulators often combine these types of ingredients to achieve synergistic effects, improving the solubility and skin penetration of active compounds within the product. Based on the properties and common uses of these ingredients, they are compatible and frequently formulated together in skincare products.