Delivery Systems and Marketing Claims for PDRN in Serums and Creams

For formulations containing PDRN (Salmon DNA), which is a relatively large molecule, choosing an effective delivery system is crucial to ensure the active ingredient can penetrate the skin barrier effectively. Since you are developing both a serum (90:10) and a cream (80:20), I recommend the following delivery systems that offer both high efficacy and strong marketing claims:

1. Ethoxydiglycol (e.q. Transcutol)

This is the industry standard for penetration enhancement. It is highly effective at carrying active ingredients deep into the skin without irritation.

• Marketing Point: It is widely recognized in clinical-grade skincare as a "Penetration Enhancer" that ensures active ingredients reach their target.
• Suitability: Perfect for both your serum and cream as it is water-soluble and easy to incorporate.
• Usage: 1-10% (typically 3-5% is sufficient).

2. PhosphoMax™ (Natural Phospholipid)

Phospholipids are "skin-identical" molecules that form the structure of cell membranes. Using them as a delivery system creates a liposome-like effect.

• Marketing Point: You can claim a "Bio-Liposomal Delivery System" or "Skin-Identical Carrier." It not only delivers PDRN but also helps repair the skin barrier.
• Suitability: Excellent for the cream (80:20) as it can also act as a natural emulsifier, providing a premium, silky texture.
• Usage: 1-3%.

3. PhosCare™ (Water Soluble Phospholipid)

If you want the benefits of phospholipids in a very easy-to-use, clear format for your serum.

• Marketing Point: Provides a "Phospholipid Delivery System" while maintaining the clarity and light feel of a serum.
• Suitability: Ideal for the serum (90:10) because it is fully water-soluble and won't cloud the formula.
• Usage: 1-5%.

Recommended PDRN Options

To maximize your "Trademark" and "Test Results" claims, you may consider these PDRN sources:

• Salmon DNA (PDRN) 5000ppm Solution: A ready-to-use liquid form, very convenient for serum production.
• Salmon DNA (PDRN) 95% Micronized Flake: A high-concentration powder for maximum potency claims.
• DNA-MAX™ Rose (Rose PDRN): A plant-derived PDRN alternative if you want to market a "Vegan PDRN" or "Plant-based DNA" concept.

Summary for your formulas:

• Serum (90:10): Use Ethoxydiglycol + PhosCare™ for maximum penetration and a premium phospholipid claim.
• Cream (80:20): Use Ethoxydiglycol + PhosphoMax™ to enhance delivery and create a luxurious, skin-repairing texture.