Dissolving Glabridin 40% in Butylene Glycol
คำถาม
Hello!
I would like to ask about the dissolution method. I have tried dissolving Glabridin 40% at a concentration of 0.05% in Butylene Glycol at 2% and mixed them together. However, the Glabridin did not dissolve completely; there are still particles dispersed in the glycol. I would like to know if Glabridin should actually dissolve until it is clear, and what additional methods should be used to help with the dissolution?
Thank you.
คำตอบ
Hello!
I understand the issue you are facing. Dissolving Licorice Extract (Glabridin 40%) in Butylene Glycol can be challenging if the right method is not used.
Based on the product information for Glabridin 40% (ID 1503) and Butylene Glycol (ID 320), Glabridin 40% is soluble in Glycols like Butylene Glycol or Propylene Glycol, as well as Ethanol. However, achieving complete clarity may require additional techniques.
Regarding whether Glabridin should dissolve until clear: Yes, under appropriate conditions, Glabridin 40% should dissolve in Butylene Glycol to form a homogeneous and relatively clear solution. The presence of dispersed particles indicates incomplete dissolution.
Here are some methods to improve the dissolution of Glabridin 40% in Butylene Glycol:
- Use Gentle Heat: Try warming the Butylene Glycol slightly (around 40-50°C) before adding the Glabridin. Heat can significantly improve dissolution efficiency.
- Increase the Butylene Glycol Amount in the Dissolution Step: Even if the final concentration in your formula is 2% Butylene Glycol, in the preparation step, you should use a sufficient amount of Butylene Glycol to completely dissolve the 0.05% Glabridin first. You can use the entire 2% Butylene Glycol available in your formula to dissolve the 0.05% Glabridin in a separate container, and then add this solution to the rest of your formula. Using a higher ratio of Butylene Glycol to Glabridin in the initial dissolution step will facilitate easier dissolution.
- Continuous Stirring and Time: After adding Glabridin to the warmed Butylene Glycol, stir continuously until it is completely dissolved. This may take some time.
- Consider a Co-solvent: If Butylene Glycol alone is still difficult, you might consider using a small amount of another suitable solvent where Glabridin dissolves well, such as Propylene Glycol or Ethanol (if your formula allows), to help with the initial dissolution step.
In summary, using gentle heat and ensuring a sufficient amount of Butylene Glycol is used in the initial dissolution step are key.
I hope this information is helpful! If you have any further questions, feel free to ask.
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Butylene Glycol
