Dissolving Piroctone Olamine Without Ethanol for Facial Cream

To dissolve Piroctone Olamine for use in a facial cream without using ethanol, you can use alternative glycol solvents. Piroctone Olamine is typically used in leave-on products like facial creams at a maximum concentration of 0.1% according to Thai FDA regulations.

Suitable alternative solvents include:

• Propylene Glycol
• Butylene Glycol
• Pentylene Glycol
• Hexylene Glycol

These glycols can act as solvents to help incorporate the Piroctone Olamine powder into your cream formulation.

Mixing Steps:

1. Pre-dissolve: Take the required amount of Piroctone Olamine powder (up to 0.1% of your total formula) and add it to a small amount of your chosen glycol (e.g., Propylene Glycol, Butylene Glycol, Pentylene Glycol, or Hexylene Glycol). The exact amount of glycol needed will depend on the concentration of Piroctone Olamine and the specific glycol used, but start with just enough to fully wet and dissolve the powder.
2. Mix Thoroughly: Stir or mix the Piroctone Olamine and glycol mixture until the powder is completely dissolved and you have a clear solution.
3. Incorporate: Add this pre-dissolved Piroctone Olamine solution into the appropriate phase of your cream formulation. This is typically added to the water phase or incorporated during the emulsification process, depending on your specific cream formula structure.
4. Final Mixing: Continue with your standard cream manufacturing process, ensuring the Piroctone Olamine solution is evenly dispersed throughout the cream.

Important Note: Avoid heating the Piroctone Olamine mixture above 80°C during the process.