Eye Cream Formulation Advice for Wrinkles

Thank you for your question and for sharing your proposed eye cream formulas! It's great that you are exploring different combinations of active ingredients to target wrinkles.

The staff's request for more details about your skin type, age, and specific concerns is very important. Providing this information will help tailor the advice to your individual needs, as different ingredients and concentrations might be more suitable depending on whether your primary concern is fine lines, deep wrinkles, puffiness, or dark circles.

Based on the ingredients you've listed, here is some information about their properties and how they can help with wrinkles and the eye area:

• Hyaluronic Acid Gel Base: This serves as a lightweight, moisturizing base for your eye cream, providing hydration without feeling heavy.
• Metabiotics Resveratrol (ActiveRelease™ Trans-Resveratrol): Known for its antioxidant and anti-aging benefits. It can stimulate collagen production, help protect against UV damage, reduce inflammation, and improve skin elasticity and hydration, which helps reduce the appearance of wrinkles. It typically requires a usage rate of 1-3% and needs specific storage conditions (refrigeration, avoid light/air) and the addition of ActiveProtec™ OX 1% for stability.
• Pep-Coll: A peptide that effectively stimulates the skin's natural collagen production. Research shows it can significantly reduce wrinkles in terms of width, length, and depth. The recommended usage rate is often around 3%, with a range of 1-5%. It should be added in the final step below 40°C and stored in the refrigerator.
• Argireline (Acetyl Hexapeptide-8): This peptide works by reducing muscle contractions, which helps to smooth out expression lines, particularly around the eyes and forehead. It is considered gentle and safe. It is often used in combination with collagen-stimulating peptides like Pep-Coll or Matrixyl 3000. It is recommended for existing wrinkles at a usage rate of 3-10% and should be mixed below 40°C within a pH range of 3.5-6.5. Store in the refrigerator.
• Matrixyl (Pal-GHK, Pal-GQPR (eq Matrixyl 3000)): This peptide blend stimulates collagen synthesis and helps improve skin firmness, elasticity, and hydration, leading to reduced wrinkles. It also contains components that help reduce inflammation. Like Argireline, it pairs well with muscle-relaxing peptides. Recommended usage is 3-5% (often 3%), mixed below 40°C, and stored in the refrigerator.
• REGU-AGE: Specifically designed for the eye area, this ingredient helps reduce dark circles and puffiness. It also strengthens the skin around the eyes and offers some protection against UV damage and inflammation. It is typically used at 2-5% and should be mixed below 40°C within a pH range of 5.0-8.0 (ideally 5-6.5). Store at room temperature or in the refrigerator, protected from light and heat.
• Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate): A synthetic peptide that mimics the effect of snake venom to instantly relax facial muscles, reducing the appearance of expression lines within hours. Its effect is temporary (6-12 hours), so daily use is needed for continuous results. It can be combined with other long-term anti-aging ingredients. The optimal usage rate is 1-4% (4% being most effective). It has specific pH requirements (3.5-6.5) and incompatibilities with certain preservatives and detergents. Store in a cool place (5-15°C), avoiding light and heat.
• Repair Activator (Bifida Ferment Lysate): This ingredient helps repair skin DNA damage, particularly from UVA exposure, boosting the skin's natural repair process. It can be used at a high rate (5-100%) and should be mixed directly into water-based formulas in the final step, avoiding heat. Store in the refrigerator.

Review of Your Proposed Formulas:

All your proposed formulas combine ingredients known for their anti-aging properties, targeting different aspects like collagen production and muscle relaxation. They are good starting points.

• Formula 1: Combines collagen stimulators (Pep-Coll, Matrixyl, Resveratrol) with a muscle relaxant (Argireline) and an ingredient for dark circles/puffiness (REGU-AGE). This is a comprehensive formula.
• Formula 2: Similar to Formula 1 but replaces Resveratrol with Syn-Ake, adding an ingredient for more immediate muscle relaxation effect.
• Formula 3: Focuses on DNA repair (Repair Activator), muscle relaxation (Argireline), and collagen stimulation (Matrixyl, Pep-Coll).
• Formula 4: Starts with Repair Activator and Argireline. To address wrinkles comprehensively, adding a collagen-stimulating peptide like Pep-Coll or Matrixyl, or an ingredient for specific eye concerns like REGU-AGE, would be beneficial, depending on your needs.

Further Recommendations:

To help you choose or refine the best formula, please provide the details requested by the staff:

• Skin Type: (e.g., dry, oily, combination, sensitive)
• Age: (This helps understand typical aging concerns)
• Current Skin Concerns: (e.g., fine lines, deep wrinkles, crow's feet, puffiness, dark circles, loss of firmness)
• Desired Outcome: (What do you hope the eye cream will achieve?)

Knowing this will allow for more specific recommendations on which ingredients and concentrations would be most effective for you. For example, if puffiness and dark circles are major concerns, REGU-AGE is a key ingredient. If deep expression lines are the main issue, a higher concentration of Argireline or the addition of Syn-Ake might be considered, alongside collagen boosters for overall skin structure.

Remember to follow the specific mixing instructions, usage rates, pH requirements, and storage conditions for each ingredient to ensure their stability and effectiveness.

Once you provide more details, we can offer more tailored guidance on adjusting your formulas.