Formula Review: Combining Peptides for Wrinkle Reduction and Preservation

Question

I have a 50g formula intended for wrinkle reduction that includes both Pep-Coll (Palmitoyl Tripeptide-5) and Matrixyl 3000 (Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7).

Could you please review this formulation and advise on:

The effectiveness of using both Pep-Coll and Matrixyl 3000 together?
Whether a preservative is needed, and if so, what type and concentration is recommended for a 50g formula?

MySkinRecipes Expert · Accepted Answer

Based on the feedback regarding your 50g formula: The staff noted that using both Pep-Coll (Palmitoyl Tripeptide-5) and Matrixyl 3000 (Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7) results in overlapping effects, which increases cost without significantly boosting efficacy. It is recommended to choose either Pep-Coll or Matrixyl 3000, but not both. Additionally, it is strongly recommended to add a preservative, such as Phenoxyethanol SA, at 1.0% (0.5g for a 50g formula) to prevent microbial contamination. The remaining amount in your 50g formula would be water.