Formula with multiple whitening agents: Irritation concerns and recommendations

Question

I have a formula containing multiple whitening agents: Azelaic Acid, Tranexamic Acid, and Alpha Arbutin. Can this formula be mixed? Are there concerns about potential skin irritation due to the combination and concentrations of these whitening agents? What are the recommendations for reducing potential irritation? Is Phenoxyethanol suitable as a preservative, or is there a better alternative like Phenoxyethanol SA? What precautions, such as patch testing, should be taken before full application?

MySkinRecipes Expert · Accepted Answer

Based on the discussion, the staff reviewed your proposed formula and confirmed it can be mixed. However, they raised concerns about potential skin irritation due to the combination of multiple whitening agents (Azelaic Acid, Tranexamic Acid, Alpha Arbutin) at the concentrations listed. The staff recommended reducing the concentration of these whitening ingredients or removing some of them to make the formula gentler. They also strongly advised performing a patch test on a small area of skin before full application to ensure tolerance. Additionally, they suggested using Phenoxyethanol SA (ID 928) instead of the standard Phenoxyethanol (ID 155) as it is less likely to cause irritation.

In summary, the formula is mixable, but caution is advised regarding the whitening agents. Please follow the staff's recommendations to adjust the formula and perform a patch test.