Formulating with LHA (Capryloyl Salicylic Acid) and Allantoin
คำถาม
I want to formulate a product containing both LHA (Capryloyl Salicylic Acid) and Allantoin. I was initially considering using LHA at a concentration of 10-20% in a water-based formula with 0.5% Allantoin, adding a preservative, and targeting a pH of 3-4.
Could you please provide guidance on the following:
- What are the appropriate usage concentrations for LHA and Allantoin when formulating them together?
- How should LHA and Allantoin be dissolved (e.g., in the water phase, oil phase, and does it require heat)?
- What is the suitable pH range for a formula containing both ingredients?
คำตอบ
LHA and Allantoin Formulation Guidelines
Based on the properties of the ingredients, here are some guidelines for formulating with LHA (Capryloyl Salicylic Acid) and Allantoin:
LHA (Capryloyl Salicylic Acid): This ingredient is typically used at a concentration of 0.5-5%, with a recommended maximum of 2% to avoid irritation. It is a powder that needs to be dissolved in the oil phase of a formulation by heating to 70-80°C.
Allantoin: This ingredient is commonly used at a concentration of 0.1-2.0%, with 0.5% being a recommended usage rate due to its solubility in water at room temperature (up to 0.5% at 25°C). It can be dissolved in the water phase.
For a formulation containing both, you would typically incorporate LHA into the oil phase and Allantoin into the water phase before combining them into an emulsion (like a cream or lotion). The final pH for Allantoin is best within the range of 4-8.
Always adjust the concentration based on skin type, using lower concentrations for sensitive skin.
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