Formulation of Water-Based Gel Serum with NanoTXA, PDRN, and Copper Peptide

Asked by: Maritahanson On: April 08, 2026 Product Type: Cosmetics

Question

Please help me with a formulation for a water-based gel serum using the following ingredients:

  • NanoTXA emulsion
  • Salmon DNA PDRN
  • Pep-R-Synthe-6
  • Copper Peptide (Tripeptide-1)
  • Hyaluronic acid (Low MW and High MW)

I have a 1% HA powder in water solution as a base. I would like to use 10% of each active ingredient for a 30 ml serum and EUXYL PE 9010 as a preservative.

Answer

This formulation for a 30 ml Water-Based Gel Serum uses your 1% Hyaluronic Acid solution as the base and incorporates high-performance actives at the concentrations you requested.

Serum Formulation (Total 30 ml)

Ingredient Percentage (%) Amount for 30 ml Function
1% Hyaluronic Acid Solution (Base) 59% 17.7 ml Hydrating Base / Gelling Agent
Nano-TXA™ (Tranexamic Acid Nano Emulsion) 10% 3.0 ml Whitening & Penetration Booster
Salmon DNA (PDRN) 5000ppm Solution 10% 3.0 ml Skin Repair & Regeneration
Pep®-Synthe6 (Palmitoyl Tripeptide-38) 10%* 3.0 ml Anti-Wrinkle Peptide
Copper Peptide (GHK-Cu) 1000ppm Solution 10%* 3.0 ml Scar Repair & Anti-Aging
PE 1090 Preservative (Extra Pure) 1% 0.3 ml Broad-spectrum Preservative
  • *Note: The standard recommended usage rate for Pep®-Synthe6 is 2%, and Copper Peptide (1000ppm) is 1-3%. Using them at 10% creates an extremely high-potency formula. Please perform a patch test before full application.*

Mixing Instructions

  1. Prepare the Base: Use your 1% Hyaluronic Acid solution. For a professional feel, a blend of Hyaluronic Acid Standard Molecule and Hyaluronic Acid Large Molecule is recommended.
  2. Add Actives: Add Nano-TXA™, Salmon DNA, and Pep®-Synthe6 to the base one by one, stirring gently until the mixture is uniform.
  3. Add Copper Peptide: Add the Copper Peptide solution last. The serum will naturally turn a light blue color.
  4. Preserve: Add the PE 1090 Preservative and mix thoroughly.
  5. Check pH: Use a pH meter or strip to ensure the final pH is between 4.5 and 7.0. This range is critical for the stability of both the Copper Peptide and Nano-TXA™.

Critical Precautions

  • No EDTA: Do NOT add Disodium EDTA to this formula. EDTA will bind with the copper ions, making the Copper Peptide ineffective.
  • Temperature: Mix all ingredients at room temperature. Do not use heat, as it can degrade the peptides and DNA.
  • Storage: Store the finished serum in a cool, dark place (refrigerator is ideal) to maintain the potency of the active ingredients.

Related Categories

Anti-Aging / Wrinkle
Cosmetics > Active Ingredients > Anti-Aging / Wrinkle
Whitening / Skin Radiance
Cosmetics > Active Ingredients > Whitening / Skin Radiance