HPMCP Solubility in Alcohol for Cosmetic/Food Coating
Asked by: Anonymous
On: September 08, 2025
Product Type:
Cosmetics
Question
I would like to inquire about Hydroxypropylmethyl Cellulose Phthalate (HPMCP, 170cP).
- Is it soluble?
- What percentage of alcohol is required for dissolution (specifically Ethanol, or what type of alcohol is recommended)?
- Could you provide recommendations for mixing the solution, including:
- Recommended temperature
- Stirring method
- Soluble concentration
- This is for its use as a coating in cosmetics or food. Please provide technical details and precautions for dissolution.
Answer
Hydroxypropylmethyl Cellulose Phthalate (HPMCP) is a cellulose derivative widely used as a film coating, particularly for enteric-coated tablets. A key property of HPMCP is its pH-dependent solubility, meaning it does not dissolve in acidic conditions (e.g., in the stomach) but is readily soluble in alkaline conditions (e.g., in the intestines).
Regarding your questions about alcohol solubility and its use as a coating in cosmetics or food:
- Solubility in Alcohol: HPMCP is generally soluble in certain organic solvents, such as alcohol (ethanol), or mixtures of alcohol and water. However, the exact recommended alcohol concentration is not specified in our product information. Typically, HPMCP tends to dissolve well in high-concentration ethanol (e.g., 70-95%) or in mixtures of ethanol with water or other organic solvents like acetone or methanol, depending on the grade and substitution level of the HPMCP.
- Recommended Alcohol: Ethanol is a commonly used and recommended alcohol for dissolving HPMCP due to its safety and acceptance in pharmaceutical, food, and cosmetic industries.
- Mixing Recommendations:
- Temperature: Dissolving HPMCP is often more effective at room temperature or slightly warmed (approximately 25-40°C) to help increase the dissolution rate.
- Stirring: Continuous and consistent stirring should be used to ensure HPMCP is evenly dispersed in the solvent and to prevent clumping. Medium to high-speed stirring will help accelerate dissolution.
- Soluble Concentration: The appropriate concentration for coating applications typically ranges from 5-15% by weight, depending on the desired viscosity and the type of HPMCP (e.g., HPMCP, 170cP or HPMCP, 40cP). The 170cP grade will yield higher viscosity than the 40cP grade at the same concentration.
- Order of Addition: HPMCP powder should be added slowly to the solvent while stirring to ensure proper dispersion and prevent lump formation.
- Dissolution Precautions:
- Clumping: HPMCP has a tendency to clump when exposed rapidly to solvents. Add the powder slowly to the solvent with continuous stirring.
- Moisture: HPMCP should be stored in a cool, dry place to prevent moisture absorption, which can affect its dissolution properties.
- Compatibility: Check the compatibility of HPMCP with other ingredients in your formulation, especially if using mixed solvents.
HPMCP (both 170cP and 40cP) is suitable for applications requiring durable film coatings and controlled release, particularly in food or pharmaceutical products needing protection from acidic environments.
