Compatibility of Ingredients: Bakuchiol, Zinc PCA, Disodium EDTA, and DMAE

Based on the information regarding the stability of Bakuchiol and the properties of the other ingredients:

• Disodium EDTA and Zinc PCA: Yes, if your formula contains Zinc PCA, Disodium EDTA will bind with the Zinc ions (Zn²⁺) present in Zinc PCA. Disodium EDTA is a chelating agent specifically designed to complex with metal ions. When both are present, the EDTA will chelate the Zinc ions.

• Implication for Bakuchiol Stability: The primary purpose of adding a chelating agent like Disodium EDTA or Phytic Acid to a Bakuchiol formula is to bind trace metal ions that can cause Bakuchiol to degrade, thereby improving its stability. If Zinc PCA is also present, the Disodium EDTA will bind to the Zinc ions from Zinc PCA. This means that the amount of Disodium EDTA available to chelate other potentially problematic trace metal contaminants in the formula might be reduced. While you can include both, the effectiveness of the chelating agent in fully protecting Bakuchiol from other metal ions could be impacted depending on the concentrations of Zinc PCA and the chelating agent.

• DMAE, Disodium EDTA, and Bakuchiol: Based on the available information about DMAE, Disodium EDTA, and Bakuchiol, there is no indication of a specific incompatibility or problem when mixing DMAE with Disodium EDTA or Bakuchiol in a formulation. DMAE functions differently and is not known to interfere with the chelating action of EDTA or the stability of Bakuchiol in the way that metal ions do.