Advice on Ingredient Dissolution and Cream Usage

Here is some advice regarding the dissolution of GentiWhite and Glycoprotein, and the usage of your cream formulation.

Dissolution of GentiWhite and Glycoprotein

Based on the product information:

• GentiWhite™ (Methyl Gentisate): This ingredient dissolves in water. The description notes that using heat not exceeding 60°C for a short period can help it dissolve faster and easier. However, the general mixing instruction is to mix in water, avoiding heat. It's possible the 'avoid heat' refers to adding it to the final formulation phase. To ensure complete dissolution, try dissolving GentiWhite in a portion of the water phase using gentle heat (up to 60°C) with good stirring until fully dissolved before incorporating it into the main batch.
• Glycoprotein: This ingredient also dissolves in water. The mixing method specifies mixing in water while avoiding heat exceeding 40°C. Dissolve Glycoprotein in a separate portion of the water phase, ensuring the temperature stays below 40°C, with adequate stirring until completely dissolved.

Recommendation: Try dissolving each ingredient separately in a suitable amount of the water phase according to their specific temperature guidelines (up to 60°C for GentiWhite briefly, below 40°C for Glycoprotein). Ensure each is fully dissolved before combining the solutions or adding them to the rest of the formulation's water phase. Insufficient water volume, temperature issues, or inadequate mixing time are common reasons for incomplete dissolution.

Usage Frequency of Your Cream

Your cream contains Tranexamic Acid 3% and Hydro White 1%, along with anti-wrinkle and moisturizing ingredients, and no exfoliants.

• Tranexamic Acid: Tranexamic Acid at a 3% concentration is generally considered safe and effective for topical use and can typically be applied twice daily, in the morning and at night.
• Formula Composition: The absence of exfoliants and the presence of moisturizing and anti-wrinkle ingredients suggest that the formula is designed to be gentle and suitable for regular use.
• Hydro White: The suitability for morning and night use also depends on the specific type of Hydro White used and whether it causes photosensitivity. Assuming Hydro White is a stable whitening agent compatible with the formula and doesn't significantly increase sun sensitivity, using the cream both morning and night should be acceptable.

Recommendation: Based on the ingredients mentioned (especially Tranexamic Acid and the lack of exfoliants), the cream appears suitable for use both in the morning and before bed. However, it is always recommended to perform a patch test on a small area of skin first to check for any adverse reactions. Additionally, when using products with brightening ingredients like Tranexamic Acid and Hydro White, it is crucial to always apply sunscreen in the morning to protect your skin and maximize the benefits of the whitening agents.

If the factory continues to have dissolution issues after trying the recommended methods, they may need to review the total water phase volume, mixing equipment, and the quality/particle size of the raw materials.