Ingredient Suitability in Soap

Based on the ingredients you listed and their properties, using this specific combination at a total concentration of 10% in soap is generally not recommended.

Here's why:

• pH Instability: Soap typically has a high pH (alkaline). Several of the ingredients you listed, such as Vitamin C (L-ascorbic acid), Salicylic Acid, Safe-B3 (Niacinamide), and Adenosine, are sensitive to high pH. At the alkaline pH of soap, these ingredients can degrade quickly, losing their effectiveness. For example, L-ascorbic acid requires an acidic pH (2.0-4.0) for stability, while Niacinamide's optimal pH range is 4.0-7.0.
• Solubility and Mixing: Some ingredients, like the standard Salicylic Acid powder, are not water-soluble and require specific solvents to incorporate properly. While some forms of Vitamin E are oil-soluble, others are water-soluble. Ensuring proper dispersion and stability of all these different types of ingredients in a soap base can be challenging.
• Recommended Usage Rates: The recommended usage rates for individual ingredients vary. While some might be used at concentrations up to 5% or 10%, others have much lower recommended maximums (e.g., Vitamin E is typically used at 0.1-1%, Salicylic Acid at 0.1-3% for wash-off products). Using a blend totaling 10% could easily exceed the safe or effective concentration for one or more components.
• Ichthammol's Properties: Ichthammol has a strong odor and is typically used at lower concentrations (2-3% for wash-off products). Using it as part of a 10% blend might result in an overpowering smell.
• Wash-off Product Limitations: In a wash-off product like soap, the contact time with the skin is very short. Many active ingredients require longer contact to be effective. While some ingredients might offer minor benefits in a wash-off, the full potential of ingredients like Vitamin C, Niacinamide, or Adenosine is usually realized in leave-on products.

Combining multiple active ingredients in a single formulation requires careful consideration of compatibility, stability, efficacy, and safety at the intended usage concentration and product type. For soap, which has a high pH and is a wash-off product, many of the ingredients you listed are not ideally suited for inclusion at high concentrations.

It would be more effective to select ingredients specifically known to be stable and beneficial in soap formulations and use them within their recommended guidelines.

• Vitamin E (Tocopheryl Acetate): Can be used as an antioxidant for the oils in the soap, but its skin benefits might be limited in a wash-off product.
• Salicylic Acid (BHA): Requires specific formulation techniques for stability at high pH, and its effectiveness is best in leave-on products. FDA limits apply.
• Ichthammol: Can be used in wash-off products for its properties, but the concentration and odor need careful management.
• Vitamin C (L-ascorbic acid): Highly unstable at soap pH. Other, more stable forms of Vitamin C might be considered, but their efficacy in wash-off products still varies.
• Lift-Now (Pullulan): Provides temporary tightening, which is not a primary benefit for a wash-off product.
• Safe-B3 (Vitamin B3, Niacinamide): Unstable at soap pH and can convert to Niacin, potentially causing flushing.
• Adenosine Liposome (or Pure-Adenosine™): Stability and efficacy are compromised at soap pH.

Therefore, using a 10% blend of these specific ingredients in soap is not advisable due to the reasons mentioned above.