Inquiry about Penetration Enhancers and Salicylic Acid EZ™ in Thin Gel Formulas

Subject: Re: Inquiry about Penetration Enhancers

Hello,

Thank you for your follow-up and pointing out the discrepancy regarding PE-1 Aqua. We apologize for the previous error.

Regarding your points:

1. Comparison of Laurocapram, 1,2-Hexanediol, and PE-1 Aqua: You are correct. Based on the product description, PE-1 Aqua is designed to enhance the penetration of water-soluble ingredients. The previous information provided was incorrect. There is no definitive test data comparing the penetration efficiency of Laurocapram and 1,2-Hexanediol for water-soluble actives.

2. Reservoir-Tech in a thin gel: As previously mentioned, adding 3% Reservoir-Tech to a very thin gel (0.2-0.3% Pro Polymer) might lead to separation. Laurocapram, being water-soluble, would be more suitable for thin, water-based formulas.

3. Compatibility with Laurocapram: You asked specifically about the compatibility of Salicylic Acid EZ™ (water-soluble type) with Laurocapram. Yes, Salicylic Acid EZ™ (water-soluble) can be used with Laurocapram in a formulation. Both are compatible with water-based systems, and Laurocapram can help enhance the penetration of water-soluble substances like Salicylic Acid EZ™. However, as the staff previously noted, Salicylic Acid primarily works on the surface of the skin for exfoliation and treating clogged pores, so increasing its penetration deeper into the skin may not provide additional functional benefits.

We hope this clarifies your questions.