Issue with Cooling Agents in Children's Mouthwash

It appears the tooth pain and gum sensitivity experienced after using the mouthwash formulation are likely due to the concentration of the cooling agents used.

Based on the typical usage rates for mouthwash:

• WS-23 Cooling Agent: Recommended usage is 5-200 ppm.
• WS-3 Cooling Agent: Recommended usage is 5-200 ppm.
• WS-12 Cooling Agent: Recommended usage is 5-100 ppm.

You mentioned using these cooling agents at a concentration of 0.3%, which is equivalent to 3000 ppm. This concentration is significantly higher than the maximum recommended levels for all three cooling agents in mouthwash formulations.

Using cooling agents at concentrations far exceeding the recommended range can cause irritation, a burning sensation, or pain in the oral cavity, including the teeth and gums. The symptoms you described are consistent with this over-concentration.

Solution

To resolve this issue, you need to significantly reduce the concentration of the cooling agents in your mouthwash formula. We recommend using each cooling agent within its specified usage range for mouthwash. You may want to start at the lower end of the recommended range (e.g., around 5-10 ppm for each) and gradually increase the concentration while testing the formulation to achieve the desired cooling effect without causing irritation.

Remember that combining multiple cooling agents can have a synergistic effect, so the total cooling sensation might be higher than expected when simply adding individual effects. Always test the final formulation for safety and comfort, especially for a children's product.