Optimal pH and Base Compatibility for QD-365 Anti-Acne Complex

For formulating with QD-365 Anti-Acne Complex, here are the technical recommendations:

1. Recommended pH Level

The ideal pH for a formulation containing QD-365 Anti-Acne Complex is between 5.0 and 6.0.

• Reasoning: This range ensures the stability of its key components. Specifically, Potassium Azeloyl Diglycinate (a derivative of Azelaic Acid) is most stable and effective in this range. If the pH is too low (below 4.0), there is a risk that the ingredient may become less stable or precipitate.

2. Base Requirements

• Acid Resistance: You do not necessarily need a specialized acid-resistant base (like those used for high-concentration AHAs at pH 3). A standard cream, gel, or serum base that is stable within the pH 5.0–6.0 range is perfectly suitable.
• Solubility: Since the complex is water-soluble, it can be easily incorporated into water-based formulas or the water phase of emulsions.

3. Usage Instructions

• Usage Rate: 0.5% – 3.0%.
• Mixing Method: It is highly recommended to add this ingredient in the final step of the mixing process.
• Temperature: Avoid high heat. Add it when the mixture has cooled down (below 40°C) to preserve the efficacy of the botanical extracts and active derivatives.

If your formula includes other acidic ingredients that push the pH below 5.0, you should use a pH adjuster (such as Triethanolamine) to bring it back to the recommended 5.0–6.0 range.