pH Stability for Matrixyl 3000 and Argireline Peptides

Asked by: maigonix On: May 19, 2016 Product Type: Cosmetics

Question

What is the optimal pH range for cosmetic formulations containing Matrixyl 3000 (Pal-GHK, Pal-GQPR) and Argireline (Acetyl Hexapeptide-8) to ensure their stability and efficacy?

Answer

pH Stability for Peptides (Matrixyl 3000, Argireline)

Based on the product information for Acetyl Hexapeptide-8 (equivalent to Argireline), the recommended pH range for the final formulation is 3.5-6.5. This supports the previous information you received that these peptides are slightly acidic and should not be in alkaline conditions, with a suggested lower limit around 3.5.

While the product description for Pal-GHK, Pal-GQPR (equivalent to Matrixyl 3000) does not explicitly state a pH range, peptides are generally sensitive to extreme pH levels. Given the specified range for Argireline (3.5-6.5), maintaining a formulation within this range is a good practice for peptide-containing products to help ensure their stability and efficacy.

In summary, for both Matrixyl 3000 and Argireline, it is best to formulate products within the pH range of 3.5 to 6.5 to maintain their stability and effectiveness. Avoid formulations with very low pH (below 3.5) or alkaline pH (above 6.5).

Related Products Mentioned