Poloxamer 184 Usage Concentration and Irritation
Question
I would like to inquire about the usage percentage of Poloxamer 184.
1. Is the recommended rate of not exceeding 5% specified by the FDA (อย.)?
2. Would using Poloxamer 184 at slightly higher than 5% cause irritation to the skin or around the eyes?
Answer
Poloxamer 184 Usage Concentration
The recommended usage concentration for Poloxamer 184 is typically between 0.1% and 5.0%. This range is generally suggested by the manufacturer to achieve desired efficacy.
Regarding your question about using more than 5% and potential eye irritation, based on the information available:
- The 5% limit is a manufacturer's recommendation for efficacy, not a maximum limit set by regulatory bodies like the FDA.
- Using Poloxamer 184 at concentrations slightly higher than 5% is generally not expected to cause irritation to the skin or around the eyes.
However, individual sensitivity to cosmetic ingredients can vary. Therefore, it is always recommended to perform testing with the actual user group to confirm tolerance and avoid potential irritation, especially when formulating for sensitive areas like the eye contour.
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