Preventing Crystallization in Oil Formulations
Question
I am formulating a TransDermal oil with one ingredient. This ingredient is crystallizing in the oil carrier, making the formulation unstable. I previously resolved a similar crystallization issue in a different carrier by adding a second compound. What benign compounds can I add to my oil carrier to prevent this crystallization? I am currently considering Vitamin A (Retinyl Palmitate); are there any other options?
Answer
Preventing Crystallization in Oil Formulations
Crystallization in an oil-based formulation occurs when an ingredient exceeds its solubility limit in the oil carrier. Adding a compatible oil-soluble compound can act as a co-solvent, increasing the solubility of your active ingredient and preventing crystallization.
You mentioned considering Vitamin A (Retinyl Palmitate), which is an oil-soluble option.
Here are other oil-soluble compounds that can help prevent crystallization in your oil base by improving solubility or acting as blending agents:
- Oil Blender™: Helps blend various oils and can improve the smoothness and stability of oil formulations.
- Ultra Solve™: A highly effective solvent for various oils, esters, and oil-soluble ingredients, designed to increase solubility.
- Eco Solve™: Similar to Ultra Solve™, this is a high-performance solvent that helps dissolve oils and oil-soluble vitamins, improving clarity and stability.
- Butyloctanol: A lightweight emollient and co-solvent soluble in many oils, which can enhance the solubility of other ingredients.
- Decyltetradecanol: Another emollient and co-solvent soluble in oils, useful for improving ingredient solubility.
- Isopropyl Myristate Gel: Contains Isopropyl Myristate, a common solvent for lipophilic substances, which can help improve solubility when dissolved in oil.
Experimenting with different compounds and their concentrations in your specific oil carrier is the best way to determine which one most effectively prevents your ingredient from crystallizing.
Related Products Mentioned
Ultra Solve™
Isopropyl Myristate Gel (Thixotropic)
Butyloctanol