Serum Formulation with Hyaluronic Acid Base

Yes, it is possible to create a serum using a Hyaluronic Acid base with most of the ingredients you listed. Let's look at each ingredient:

• Hyaluronic Acid: Various forms of Hyaluronic Acid, such as Hyaluronic Acid (Standard Molecule), Hyaluronic Acid (Large Molecule), Hyaluronic Acid (Super Low Molecule), or a pre-made Hyaluronic Acid Gel Base, are excellent water-based options for a serum base.

• Safe-B3™ (Vitamin B3, Niacinamide): This ingredient is water-soluble and compatible with a hyaluronic acid base. It is effective in a pH range of 3-8, with an optimal range of 4.0-7.0.

• Panthenol (Vitamin B5): Panthenol is also water-soluble and easily incorporated into a hyaluronic acid serum. It is stable in a pH range of 3.5-7.0.

• Alpha Arbutin: This is a water-soluble skin brightening agent that can be used in serums. It requires a pH between 3.5 and 6.5 for stability and to prevent breakdown into hydroquinone.

• Ethoxydiglycol: This acts as a solvent and carrier, helping to dissolve other ingredients and enhance their penetration into the skin. It is soluble in water and compatible with a hyaluronic acid base.

• 20nm Silver Pure™ (Nano Silver): This ingredient presents the main challenge when combined with the others, particularly Alpha Arbutin. Nano Silver comes in different forms, including Nano Silver 20nm Powder (insoluble) and Nano Silver (2000ppm, Colloidal, Yellow Solution) (water-soluble liquid). The liquid form of Nano Silver is typically most stable at a higher pH range (6-12) and can be sensitive to salts and cationic ingredients. This pH requirement conflicts with the optimal pH range for Alpha Arbutin (3.5-6.5). Combining Alpha Arbutin and Nano Silver in the same formula while maintaining the optimal pH for both ingredients' stability and efficacy is difficult.

Conclusion:

You can successfully formulate a serum using a Hyaluronic Acid base with Safe-B3™ (Vitamin B3, Niacinamide), Panthenol (Vitamin B5), Alpha Arbutin, and Ethoxydiglycol. However, incorporating 20nm Silver Pure™ (Nano Silver) into this specific formulation alongside Alpha Arbutin is challenging due to conflicting pH requirements and potential compatibility issues. It would be more feasible to create a serum with the other ingredients and potentially use a different preservative, or formulate the Nano Silver separately if its antibacterial properties are essential.