Serum Formulation with Nano-TXA™ and Peptide Complex

Question

I am formulating a serum and how much of Nano TXA will I use with: Salmon DNA PeP-R-Synthe-6 Copper Tripeptide-1 Acetyl Decapeptide-3 Hyaluronic acid (low MW and high MW)

MySkinRecipes Expert · Accepted Answer

To formulate a high-performance serum using Nano-TXA™ as your base along with the peptides and active ingredients you mentioned, here is the technical guidance on usage rates and mixing:

1. The Role of Nano-TXA™

Nano-TXA™ (Tranexamic Acid Nano Emulsion) is designed specifically as a Penetration Base.

Usage Rate: 90–100%.
Capacity: You can add up to 10% total of other water-soluble active ingredients into this base.
Constraint: You must not add any oil or oil-soluble ingredients, as they will disrupt the nano-emulsion structure and particle size.

2. Recommended Formula (Total 100%)

Since the total of all additional actives must not exceed 10% of the formula when using Nano-TXA™ as the base, here is a balanced recommendation:

Ingredient	Recommended %	Purpose
Nano-TXA™	90.0%	Penetration Base & Whitening (3% Tranexamic Acid)
Salmon DNA (PDRN)	5.0%	Skin repair and regeneration
Pep®-Synthe6	2.0%	Advanced anti-wrinkle (Palmitoyl Tripeptide-38)
Copper Peptide (GHK-Cu)	1.0%	Scar repair and skin firming
Pep®-Rejuline	1.8%	Elasticity and regeneration (Acetyl Decapeptide-3)
Hyaluronic Acid (High MW)	0.1%	Surface hydration and film-forming
Hyaluronic Acid (Low MW)	0.1%	Deep skin hydration

3. Mixing Instructions & Precautions

Mixing Order:
1. If your Hyaluronic Acids are in powder form, dissolve them in a tiny amount of water first to create a concentrate.
2. Combine all the water-soluble actives (Salmon DNA, Peptides, and HA solution).
3. Slowly blend this mixture into the Nano-TXA™ base until uniform.
Temperature: All these ingredients (especially the peptides and Salmon DNA) are highly heat-sensitive. Mix them at room temperature (below 40°C).
pH Control: The ideal pH for this combination is between 4.5 and 7.0. This range is optimal for both Nano-TXA™ stability and the effectiveness of Copper Peptide.
Copper Peptide Warning: Do not use Disodium EDTA in this formula. EDTA will bind with the copper ions, making the Copper Peptide ineffective.
Preservation: Since you are adding 10% of other water-based ingredients to the base, ensure your final formulation includes a suitable preservative to prevent microbial growth.