Serum Formulation with Your Ingredients

Yes, it is possible to formulate a serum for acne reduction and skin rejuvenation using the ingredients you listed. This type of formulation would likely be a water-in-silicone or water-in-oil/silicone emulsion, which can provide a lightweight feel.

Here's a breakdown of the ingredients and their roles, along with recommended usage rates based on the product information:

Silicone and Texture Enhancers

These ingredients help create a smooth, lightweight texture that spreads easily and leaves a pleasant feel on the skin.

• Cyclopentasiloxane (like Cyclopentasiloxane (Low-Odor Cyclomethicone) or KF-995 (Cylopentasiloxane, D5)): This is a lightweight, volatile silicone that provides a silky feel and evaporates quickly, contributing to a non-greasy finish.
  • Recommended Usage Rate: 1-20% in creams/lotions (can be higher in silicone-based formulas).
• Dimethicone (various viscosities like Dimethicone (Very Light/2, Volatile), Dimethicone (Very Light/5, Low-Odor), Dimethicone (Light/50, Low-Odor)): Dimethicone provides slip and a smooth feel. Different viscosities offer varying levels of richness and playtime on the skin. Volatile types evaporate quickly, while higher viscosity types provide more lasting conditioning.
  • Recommended Usage Rate: 0.5-50%. Choose the viscosity based on your desired texture.
• Dimethicone Crosspolymer (like Trifluoropropyl Dimethicone/Trifluoropropyl Divinyldimethicone Crosspolymer): Crosspolymers can thicken silicone phases and provide a silky, matte feel, helping to reduce tackiness.
  • Recommended Usage Rate: 1-50%.
• Cyclotetrasiloxane: While mentioned, a specific product was not found. Cyclotetrasiloxane is similar to Cyclopentasiloxane but evaporates faster. Due to regulatory concerns, Cyclopentasiloxane is often preferred.

Active Ingredients for Acne and Rejuvenation

These are the key ingredients targeting your skin concerns.

• Tocopheryl Acetate (Vitamin E): Acts as an antioxidant, protecting the formula and the skin from free radical damage. It also offers some skin conditioning benefits.
  • Recommended Usage Rate: 0.1-1% (0.1-0.5% for skin antioxidant effect). Using more than 0.5% may feel sticky.
• Tamanu Oil (Virgin, Madagascar, Cold-Pressed): Known for its skin rejuvenating properties, including helping to reduce the appearance of scars and promoting skin healing. It also moisturizes and softens the skin.
  • Recommended Usage Rate: 5-100% (mix in the oil part).
• Bakuchiol (Pure-Bakuchiol™): A natural alternative to retinol, offering similar benefits like stimulating collagen production, improving skin texture, and acting as an antioxidant, but with less potential for irritation. It also has properties that can help with acne by reducing sebum and inflammation.
  • Recommended Usage Rate: 0.5-1% (1% recommended for best results). It is highly recommended to use with a penetration enhancer like Dimethyl Isosorbide (2-3%) for maximum efficiency. Bakuchiol is sensitive to metal ions and pH above 6.5.
• Azelaic Acid (Liquid Azelaic™): This water-soluble form of Azelaic Acid is effective for reducing oiliness, minimizing clogged pores, reducing acne, and brightening the skin/reducing dark spots.
  • Recommended Usage Rate: 5-10% (10% recommended for whitening, brightening, and reducing oiliness/acne). It is water-soluble and works best in a pH range of 5-11.

Emulsifier

• SiliSolve Plus™: This is a crucial ingredient for combining the water-soluble Azelaic Acid phase with the oil and silicone phases (containing silicones, Tamanu Oil, Bakuchiol, and Vitamin E) to create a stable emulsion. It is a water-in-oil and silicone binder.
  • Recommended Usage Rate: 0.5-3%. Using a higher percentage might make the formula too liquid.

Important Formulation Notes

• Emulsion Type: Given the ingredients, a water-in-silicone/oil emulsion is the most suitable type.
• Mixing Procedure: Follow the instructions for SiliSolve Plus™ carefully. Typically, you would mix SiliSolve Plus™ into the silicone/oil phase first, and then gradually add the water phase while blending continuously until emulsified.
• pH Adjustment: Bakuchiol is most stable below pH 6.5, and Liquid Azelaic™ works well between pH 5-11. Aim for a final pH in the range of 5-6.5 for optimal stability and efficacy of both actives.
• Stability: Bakuchiol can be sensitive to metal ions, so consider adding a chelating agent like Disodium EDTA (around 0.1%) to the water phase. If the serum is packaged in a clear bottle, adding a UV protectant is recommended to help maintain the stability of Bakuchiol and other sensitive ingredients.
• Preservation: Any formula containing water requires a preservative system to prevent microbial growth. This was not listed in your ingredients but is essential for product safety and shelf life.
• Ingredient Percentages: Ensure the total percentage of all ingredients in your final formula adds up to 100%. Adjust the water percentage accordingly.

By carefully formulating using SiliSolve Plus™ to combine the phases and paying attention to pH and stability requirements, you can create a beneficial serum targeting both acne and skin rejuvenation with these ingredients.