Solubility and Solvent Ratios for Hi-LiconeA™ and WhiteCumin™

To achieve a clear and stable solution for Hi-LiconeA™ Licorice Extract (Licochalcone A 20%) and WhiteCumin™ (Tetrahydrodiferuloylmethane) at 0.3% each, the choice of solvent and the ratio are critical.

1. Recommended Glycol Ratios

Based on technical data and solubility studies, here are the recommended ratios for dissolving 0.3% of these powder ingredients:

Total Solvent Requirement: If you are using both in the same formula, you should aim for a total of approximately 6% – 8% solvent to ensure both remain fully dissolved and do not recrystallize over time.

2. Solvent Performance

• Pentylene Glycol & Propanediol: These will work, but they are "weaker" solvents for these specific actives compared to Ethoxydiglycol. If using only these, you may need to use the higher end of the ratio (12:1 or 15:1) and apply mild heat (40–50°C) to ensure complete dissolution.
• Ethoxydiglycol: This is the most effective solvent for WhiteCumin™. Research indicates that Tetrahydrodiferuloylmethane (THC) has significantly higher solubility in Ethoxydiglycol (approx. 126.4 mg/mL) compared to standard glycols. Using even a small amount (e.g., 2–3%) of Ethoxydiglycol in your solvent blend will greatly improve the stability and clarity of the final product.

3. Mixing Instructions

For the best results and a clear final product, follow these steps:

1. Premixing: Do not add the powders directly to the water phase.
2. Dissolution: Combine the powders with your chosen glycols (Pentylene Glycol, Propanediol, or Ethoxydiglycol).
3. Heat: Gently heat the mixture to 45–55°C while stirring until the liquid is completely clear and no powder particles remain.
4. Integration: Once clear, slowly add this premix into the main formula.
5. pH Control: Ensure the final formula pH is between 3.5–6.5 to maintain the stability of the Licochalcone A.

4. Important Clarification on Dosage

• 0.3% Powder: If you are using 0.3% of the product as supplied, the ratios above apply.
• 0.3% Active Licochalcone A: If your goal is to have 0.3% pure Licochalcone A in the formula, you would need to use 1.5% of the Hi-LiconeA™ powder (since it is a 20% extract). This would require a much higher solvent concentration (approx. 12–18% glycol) to keep it in solution.