Solubility and Stability of Actives in Squalane for Facial Application

Question

I am trying to dissolve four active ingredients in Squalane for a facial application. I have the following questions:

1. For ingredient #3 (Blueberry Pterostilbene), it was initially cloudy but became clearer after stirring, although not as perfectly clear as ingredients #1 and #2. Is this considered acceptable?
2. For ingredient #4 (AcneBee Extra), the mixture remained cloudy and did not seem to mix well. Do I need to use heat to help it dissolve?
3. Assuming all four ingredients dissolve properly in Squalane, is the resulting mixture suitable and safe for facial application?
4. Regarding Squalane itself, will it go rancid if stored for a long time? Can it be used on all skin types without causing allergic reactions?

MySkinRecipes Expert · Accepted Answer

Based on the staff's response regarding dissolving the four actives in Squalane: Blueberry Pterostilbene (#3): The staff believes that the mixture becoming clearer after stirring, even if not perfectly transparent like #1 and #2, should be acceptable. If separation occurs later, they suggest using Oil Blender to help emulsify it. AcneBee Extra (#4): Since it remained cloudy and didn't seem to mix well, the staff recommends trying gentle heating to 50-60°C and stirring gently to aid dissolution. General Dissolution and Facial Use: The staff confirms that dissolving these four actives in Squalane is appropriate for facial application. They note that when dissolved in Squalane (which acts as a base), the mixture should ideally become clear. Squalane Properties: Squalane is highly stable and very unlikely to go rancid, especially if it is of high purity. Rancidity is more probable if impurities from the olive source are present and oxidize. Regarding skin types, while Squalane is generally well-tolerated, suitability depends on individual skin needs and does not guarantee that it won't cause an allergic reaction for everyone.