Stability of Ascorbyl Tetraisopalmitate at Low pH

Ascorbyl Tetraisopalmitate, such as our product Perfect-C™, is generally not stable at pH levels below 5. The optimal pH range recommended for formulations containing Ascorbyl Tetraisopalmitate is typically between 5.0 and 5.5.

Attempting to create a serum combining L-ascorbic acid and Ascorbyl Tetraisopalmitate at a low pH like 3 is not recommended. L-ascorbic acid requires a low pH (typically below 3.5) for stability and absorption, while Ascorbyl Tetraisopalmitate requires a higher pH range (5.0-5.5). Combining them at pH 3 would likely lead to the degradation of the Ascorbyl Tetraisopalmitate.

To help stabilize Ascorbyl Tetraisopalmitate in a formulation, ensure the pH is maintained within the recommended range of 5.0-5.5. If your formula contains water, it is also recommended to include Disodium EDTA at a concentration of 0.2% to help chelate metal ions that can cause degradation.