Strong Tablet Binders for Hardness
คำถาม
I am formulating a tablet with Microcrystalline Cellulose (80%), Magnesium Stearate (2%), pigment (8%), and active ingredient (10%). The tablets I produced are not hard enough. What are some very strong tablet binders or glues that I can use, and what are their recommended usage rates?
คำตอบ
Strong Tablet Binders
Based on your current tablet formulation which is not hard enough, you can add a stronger binder to improve the tablet's hardness and integrity. Here are a couple of options:
Polyvinylpyrrolidone K90 (PVP-K90): This is considered a very strong binder commonly used in tablet formulations to significantly increase hardness. You can try adding it to your formula, typically replacing a small percentage of your Microcrystalline Cellulose.
- Suggested Usage Rate: Start with a low percentage, such as 1-5%, and adjust based on the desired hardness. PVP-K90 is potent, so a small amount can make a big difference.
Lactose (Refined/Tablet Binder): Lactose is also used as a binder and filler in tablets. While perhaps not as strong as PVP-K90, it can contribute to tablet hardness.
- Suggested Usage Rate: The typical usage rate for Lactose as a binder is 1-20%.
When incorporating a new binder, you will need to adjust the percentage of other fillers (like Microcrystalline Cellulose) to keep the total percentage at 100%. Start with a low concentration of the binder and gradually increase it until you achieve the desired tablet hardness.
Remember that the optimal amount depends on your specific active ingredient and the desired tablet properties, so testing is recommended.
