Targeted Wrinkle Serum Formulation

Based on the ingredients and percentages you've provided, it is possible to create a serum targeting wrinkles around the eyes and forehead. The combination of ingredients you've chosen includes several peptides known for their anti-aging properties and a penetration enhancer to help deliver them into the skin.

Here's an evaluation of your proposed formula:

• Snail Venom (Mu-Conotoxin) 20%: This is within the recommended usage rate (10-20%) and is known to help reduce sudden wrinkles by inhibiting muscle constriction. The description mentions that a water-based formula with a cationic polymer like Poly-Conditioner Pro is recommended for optimal results, which aligns with your formula.
• Pro Polymer™ (Gel Maker) 0.5%: This acts as a thickener. The usage rate is within the recommended range (0.5-5%), but the general recommendation for a gel texture is 0.8%. Using 0.5% might result in a thinner serum consistency.
• Poly-Conditioner Pro (400 mPa.s) 0.5%: This functions as a cationic polymer and skin conditioning agent. The usage rate is within the recommended range (0.2-0.5%). It is also specifically mentioned as compatible with Snail Venom in a tested formula example.
• Mild Preserved Eco™ (Preservative-Free) 1%: This is a gentle preservative alternative and humectant. The usage rate is within the recommended range (0.5-2.0%) and is suitable for general cosmetic formulas.
• Acetyl Octapeptide-3 (eq. SNAP-8) 10%: This peptide helps reduce wrinkles by reducing muscle contraction. Your proposed percentage is within the recommended usage rate (3-10%).
• Wrinkle-Lax™ คลายริ้วรอย 0.3%: This ingredient has a muscle relaxant effect to help reduce wrinkles caused by muscle contraction. Your proposed percentage is within the recommended usage rate (0.3-0.5%).
• Pep®-Leupha (Pentapeptide-18) 10%: This peptide is also known for its wrinkle reduction properties. Your proposed percentage is within the recommended usage rate (3-10%).
• Dimethyl Isosorbide (DMI) 3%: This acts as a solvent and penetration enhancer, helping the active ingredients absorb better into the skin. Your proposed percentage is within the recommended range (1-10%) and is the recommended rate for transporting ingredients.

The combination of Snail Venom, Pro Polymer, Poly-Conditioner Pro, and Mild Preserved Eco at the percentages you listed is very similar to an example formula provided in the Snail Venom description that showed good effectiveness.

Mixing Guidance:

When mixing, pay attention to the heat sensitivity of the ingredients. Peptides like Snail Venom, Acetyl Octapeptide-3, Pep®-Leupha, and Wrinkle-Lax should be added in the final step when the mixture has cooled to below 40°C. Mild Preserved Eco should also be added in the final step. Pro Polymer can be mixed in the water phase, and while it can tolerate some heat (up to 65°C), considering the heat sensitivity of other ingredients, it's best to prepare the base and cool it before adding the sensitive actives. DMI can be added to the water phase and can withstand heat up to 80°C.

Overall, your proposed formula uses suitable ingredients at appropriate concentrations for a targeted wrinkle serum.