Using Phospholipid (Hydrogenated Lecithin) for Penetration Enhancement and Liposome Formation
Question
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Answer
Using Phospholipid (Hydrogenated Lecithin) as a Penetration Enhancer
Based on the product information for Phospholipid (Hydrogenated Lecithin), your proposed method for incorporating it into your formulation is generally correct and aligns with the recommended usage.
Here's a breakdown:
Dispersing Phospholipid in Water: Starting by dispersing Phospholipid in water and blending at 1000 rpm for 15 minutes is correct. This is the recommended method for initial dispersion. Crucially, ensure the water is at room temperature (no more than 40°C). Using hot water before dispersion can cause the Phospholipid to clump.
Adding Water-Soluble Actives: Adding water-soluble active ingredients dissolved in water to this dispersion is also appropriate, as you are essentially adding more components to the water phase.
Adding Oil-Soluble Ingredients: Gradually adding the oil-soluble ingredients (representing the oil phase) and blending until homogeneous is the correct next step. The product requires both a water and an oil phase to dissolve properly.
Liposome Formation and Penetration: The product description explicitly states that Hydrogenated Lecithin has the appearance of forming liposomes, which allows the formula to penetrate the skin better. Therefore, using it in this manner is intended to help carry both water-soluble and oil-soluble substances into the skin.
In summary, your method of dispersing Phospholipid in room temperature water first, then adding water-soluble actives, followed by the oil phase, and blending thoroughly is a valid approach for using this ingredient as a penetration enhancer and potentially forming liposomes.
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