Using Thyme Kill (IPMP) as an Antibacterial Agent in Liquid Toothpaste/Oral Detergent

Thyme Kill™ (o-Cymen-5-ol, IPMP) in Oral Care Formulations

Thyme Kill™ (o-Cymen-5-ol or Isopropyl methylphenol - IPMP) is highly suitable for use as an antibacterial agent in oral cavity detergent formulations, such as liquid toothpaste or mouthwash.

1. Suitability and Function

• Antibacterial Efficacy: IPMP is a well-known and effective broad-spectrum antimicrobial agent, widely used in oral hygiene products globally to combat bacteria associated with plaque, gingivitis, and bad breath.
• Safety Profile: The product description notes its "High security," making it a preferred choice for sensitive applications like oral care.
• Chemical Relation: IPMP is an isomer of Thymol (found in Thyme Care™), which is another common and effective ingredient in oral care.

2. Recommended Usage Percentage

• Maximum Limit: For cosmetic products, the FDA specifies a maximum use of 0.1%. It is critical to adhere to this limit for safety in a product intended for the oral cavity.
• Effective Range: The product is effective in killing germs mostly at a concentration of 0.05%. In oral care products, the typical usage range is often between 0.01% to 0.1%, depending on the desired level of antimicrobial activity.

3. Constraints and Compatibility

• pH Stability: IPMP is generally stable and effective across a wide pH range, making it compatible with most liquid toothpaste and mouthwash formulations.
• Solubility: IPMP is oil-soluble. In a water-based liquid toothpaste/mouthwash, it must be properly solubilized using a suitable solvent (e.g., alcohol, glycols) or a non-ionic surfactant system to ensure it remains clear and dispersed.
• Compatibility: The product description suggests using Thyme Kill™ as a Preservative Booster alongside other preservatives (e.g., Phenoxyethanol or Mild Preserved Eco) for enhanced broad-spectrum protection of the formula itself.

4. Safety Considerations for Oral Use

• High Security: At the recommended concentrations (up to 0.1%), IPMP has a good safety record for oral use.
• Taste and Sensation: While safe, IPMP has a characteristic odor and taste that may need to be masked with flavorings (e.g., mint, spearmint) to ensure consumer acceptance and a pleasant mouthfeel.
• Regulatory Compliance: Always ensure the final formulation complies with the specific regulatory guidelines for oral care products in the target market, particularly regarding the maximum allowable concentration of IPMP.