Using WS-23 Cooling Agent at 1% Concentration in Cooling Spray

Regarding your question about using WS-23 Cooling Agent (Methyl Diisopropyl Propionamide) at a 1% concentration in a cooling spray:

Can you use it at 1%?

Yes, it is possible to use it at 1%, but there are several factors you should consider:

1. Intensity of Sensation: The recommended rate of 0.1-0.5% is usually sufficient to provide a clear cooling effect. Increasing it to 1% (double the maximum recommendation) will make the sensation very intense. For some users, this may transition from "cool" to a "stinging" or "burning" sensation.
2. Skin Irritation: While WS-23 is generally milder and less irritating than menthol, using it at higher concentrations increases the risk of skin irritation, especially on sensitive areas or thin skin.
3. Solubility Issues: WS-23 is a powder that dissolves in oils, glycols, or alcohol. If you are making a water-based spray, increasing the concentration to 1% will make it harder to dissolve and keep stable in the formula without using a high amount of solubilizers or alcohol.

Is it dangerous?

It is not considered "dangerous" or toxic at 1% for topical use, but it may be uncomfortable. It is not recommended for use on the face, near the eyes, or on broken/sensitive skin at this concentration.

Recommendations:

• Start with the recommended range: Try formulating at 0.5% first. This is already a strong dose for most people.
• Patch Test: If you decide to proceed with 1%, perform a patch test on a small area of skin to ensure it does not cause redness or excessive stinging.
• Solubilization: Ensure you have enough solvent (like Ethyl Alcohol or Propanediol) to fully dissolve the powder, as undissolved particles can cause localized irritation.

Product mentioned:

• WS-23 Cooling Agent (Methyl Diisopropyl Propionamide): A high-efficiency cooling agent that provides a long-lasting cool feeling without the strong scent of menthol.