Developing a Cream with Pro-Xylane

Regarding your question about developing a cream with 30% Pro-Xylane, we would like to clarify the following:

The liquid form of Pro-Xylane (Pro-Xylane (Hydroxypropyl Tetrahydropyrantriol, Liquid) - Product ID: 7385) contains 30% active Hydroxypropyl Tetrahydropyrantriol. The recommended usage rate for this raw material in cosmetic formulations is 0.5-10% (with 5% being recommended).

Therefore, incorporating 30% of this liquid Pro-Xylane into your total formulation significantly exceeds the recommended usage rate and may lead to instability or other issues with the product. Most ready-made bases also have a limitation on additional ingredients, typically allowing no more than 10%, which aligns with the maximum recommended usage of this liquid Pro-Xylane.

For optimal and safe results, we recommend using the liquid Pro-Xylane (Product ID: 7385) at a maximum concentration of 10%. This will provide 3% active Hydroxypropyl Tetrahydropyrantriol in the final product, which is the concentration used in clinical trials and has shown excellent results in reducing wrinkles, increasing firmness, and improving skin condition.

Example Cream Formulation with Pro-Xylane (10% Usage Rate)

Here is a basic cream formulation example you can adapt, incorporating the liquid Pro-Xylane at its maximum recommended usage:

Part 1: Water Phase (Heat to 70-75°C)

• Distilled Water: 70.0%
• Glycerin: 3.0%
• Pro-Xylane (Hydroxypropyl Tetrahydropyrantriol, Liquid) (Product ID: 7385): 10.0%

Part 2: Oil Phase (Heat to 70-75°C)

• Emulsifying Wax (e.g., Glyceryl Stearate SE): 5.0%
• Caprylic/Capric Triglyceride (Light Emollient Oil): 5.0%
• Cetyl Alcohol (Thickener/Stabilizer): 2.0%

Part 3: Cool Down Phase (Add when temperature is below 40°C)

• Preservative (e.g., Phenoxyethanol & Ethylhexylglycerin): 1.0%
• Fragrance (Optional): 0.1-0.5%
• pH Adjuster (e.g., Lactic Acid or 10% Sodium Hydroxide Solution): Adjust pH to 3.8-7.0 (within Pro-Xylane's optimal pH range)

Mixing Procedure:

1. Combine all ingredients in Part 1 in a heat-resistant container. Stir well and heat to 70-75°C.
2. Combine all ingredients in Part 2 in another heat-resistant container. Stir well and heat to 70-75°C, or until all ingredients are melted and homogeneous.
3. Slowly pour Part 2 into Part 1 while continuously stirring with a hand blender (homogenizer) or high-speed stirrer until the cream begins to emulsify and become uniform.
4. Continue stirring until the cream's temperature drops below 40°C.
5. Add Part 3 ingredients one by one, stirring well after each addition.
6. Check and adjust the cream's pH to be within the range of 3.8-7.0.

If you are referring to the powder form of Pro-Xylane (Hydroxypropyl Tetrahydropyrantriol (100% Powder, eq. Pro-Xylane) - Product ID: 35956), which is 100% active, the recommended usage rate is 0.5-3%.