ActiveRelease Retinal™ Serum Formulation Guide

This guide outlines a recommended formulation structure for a serum featuring ActiveRelease Retinal™, incorporating essential ingredients for optimal performance and stability.

Key Ingredients and Recommended Usage:

• ActiveRelease Retinal™ (Product ID 6979): 1-5% (Recommended 3%)
  • This is the core anti-aging active ingredient.
  • Mix in a small amount of oil or a suitable solvent from your formula base. Avoid heat.
• ActiveProtec™ OX (Product ID 7752): 1%
  • Crucial for protecting ActiveRelease Retinal™ from degradation.
  • Mix in the water phase.
• Safe-B3™ (Vitamin B3, Niacinamide) (Product ID 74): Recommended usage is 2-5% (Safe-B3™ can be used up to 10%).
  • Helps improve skin tolerance to retinal and offers additional skin benefits like reducing redness and improving barrier function.
  • Mix in the water phase.
• Water Phase: Purified water forms the base.
• Humectants: Ingredients like Glycerin or Propanediol (e.g., 3-10%) to provide hydration.
• Thickener: To achieve desired serum viscosity (e.g., Carbomer, Xanthan Gum, or polymer thickener). Choose one suitable for the target pH range.
• pH Adjuster: Acid or base (e.g., Citric Acid, Sodium Hydroxide) to set the final pH.
• Preservative: Broad-spectrum preservative effective in the target pH range to prevent microbial growth.

Formulation Steps:

1. Combine purified water and humectants in a beaker.
2. Disperse or dissolve your chosen thickener in the water phase according to its specific instructions. Heat may be needed depending on the thickener; cool down if heated.
3. Add Safe-B3™ (Niacinamide) to the water phase and stir until fully dissolved.
4. In a separate small container, disperse the ActiveRelease Retinal™ powder in a small amount of oil or a compatible solvent from your formula base. Mix well to ensure even dispersion. Do not apply heat.
5. Carefully add the dispersed ActiveRelease Retinal™ mixture to the main water phase.
6. Add ActiveProtec™ OX to the mixture and stir until dissolved.
7. Mix the entire formulation thoroughly to ensure all ingredients are uniformly distributed.
8. Check the pH of the serum and adjust it to the recommended range of 3.5-6.5.
9. Add your chosen preservative and mix until incorporated.
10. Conduct final quality checks on the serum's pH, appearance, and texture.

Important Considerations:

• Storage: Store the finished serum in an opaque, airtight container away from light and heat. For long-term storage of the ActiveRelease Retinal™ powder before use, refrigeration or freezing is advised.
• pH Level: Maintaining the pH within the 3.5-6.5 range is critical for the stability of ActiveRelease Retinal™.
• Heat Sensitivity: Avoid exposing ActiveRelease Retinal™ to heat during the formulation process.
• Light and Air: Protect the final serum product from exposure to light and air to maintain its efficacy.

By following this guide and including the recommended supporting ingredients, you can create a stable and effective ActiveRelease Retinal™ serum.