Cooling Agents for Cream Formulation

To add a cooling sensation to your cream, especially with a 5% oil phase, you can use cooling agents that are soluble in oil or can be incorporated into the water phase.

Based on the staff's suggestion and product information, here are some options:

• CoolTouch™ (Menthyl Lactate): This is a popular choice for skin cooling and is gentler than traditional menthol. It is designed to be mixed into the oil phase of your formula. The recommended usage rate is 0.1-1.0%, adjustable based on the desired level of coolness.
• CoCool™ (Menthol+Menthyl Lactate): This is a blend that also provides a cooling sensation on the skin and is mixed into the oil phase. It can be used at a rate of 0.1-5%.

Other cooling agents that can be considered, depending on your formulation's water phase or desired effect:

• Menthol Water Soluble: A liquid form of menthol that is easily dissolved in water. Use rate is 0.1-5%.
• Long-Cool™ (Encapsulated Menthol): Encapsulated menthol that dissolves in water and provides a prolonged cooling sensation. Recommended usage is 1.0-5.0%.
• Menthyl PCA: Provides a long-lasting cooling effect and can release moisturizing factors. It can be mixed in water, oil, or glycols, potentially requiring heat for dissolution in oil/glycols. Usage rate is 1-20%.
• Cooling Green Beads: These beads contain encapsulated menthol and WS3, releasing coolness when broken. They are dispersed in the formulation. Usage rate is 0.1-5%.

For your cream with a 5% oil phase, CoolTouch™ and CoCool™ are excellent starting points as they are designed to be incorporated into the oil phase. You can adjust the percentage within the recommended range to achieve your preferred cooling intensity.