Adding Retinyl Acetate Powder to Cream Formulation
Question
I would like to know if the Vitamin A [url=http://www.myskinrecipes.com/shop/%E0%B8%95%E0%B9%88%E0%B8%AD%E0%B8%95%E0%B9%89%E0%B8%B2%E0%B8%99%E0%B8%A3%E0%B8%B4%E0%B9%89%E0%B8%A7%E0%B8%A3%E0%B8%AD%E0%B8%A2/1035-vitamin-a-retinyl-acetate.html:14txm4o3]Retinyl Acetate[/url:14txm4o3] powder can be dissolved in the cool-down phase of a cream formulation. The website states that it should be mixed in the water phase and can withstand heat, but I am concerned that Vitamin A might be sensitive to heat and am unsure.
Answer
Based on the information for Vitamin A Acetate (Retinyl Acetate, Water-Dispersible, 325,000 IU/g), the product description states that it can be mixed in the water phase and can withstand heat. Retinyl Acetate is also noted for its outstanding stability compared to other forms of Vitamin A.
However, as a general best practice for formulating with Vitamin A derivatives, adding them during the cool-down phase (typically below 40°C) is recommended to minimize any potential degradation from prolonged heat exposure, even if the product is described as heat-stable. This helps ensure the ingredient maintains its maximum potency over the shelf life of the product.
Therefore, while the product information indicates it can withstand heat and be added to the water phase, incorporating it during the cool-down phase is a safer approach to preserve its activity in a cream formulation.
