Adjusting pH for Vitamin C Serum Stability and Regulatory Compliance

Asked by: kalyaneechatree20 On: May 21, 2018 Product Type: Cosmetics

Question

How should I adjust the pH of Stabilized Vitamin C (Natural-C Glycol) Serum for cosmetic production to meet the regulatory requirement of pH >= 3.5, ensuring the stability of Vitamin C (L-ascorbic acid)?

Answer

Adjusting pH for Stabilized Vitamin C (Natural-C Glycol) Serum

To adjust the pH of Stabilized Vitamin C (Natural-C Glycol) Serum for cosmetic production purposes, where the FDA requires a pH of at least 3.5, you should follow these steps:

  1. Gradually add a weak base, such as Triethanolamine 99%, to the serum.
  2. Continuously measure the pH as you add the base.
  3. Stop adding the base when the pH reaches 3.5.

It is important not to adjust the pH higher than 3.5, as a higher pH can cause Vitamin C (L-ascorbic acid) to degrade more quickly.