Formulation Analysis

Feasibility and Method

The proposed mixing method involves creating two parts before combining them:

• Part A: Combining water-soluble ingredients (Minoxil Aqua, Minoxol Aqua, Biotinyl-GHK, Hydrolyzed Keratin, N-Acetyl Cysteine) in water. This is feasible as these ingredients are described as water-soluble or dispersible in water. N-Acetyl Cysteine is a powder that dissolves in water, but its low pH (2-3) means the final pH of Part A and the finished product will need careful adjustment to be within the recommended range for N-Acetyl Cysteine (pH 3-6) and for the stability of other ingredients like peptides.
• Part B: Combining Clover Flower Extract and Sandal Pentanol/Sandalore in Isopentyldiol. Clover Flower Extract (Biochanin A 98%) is a powder that dissolves in Isopentyldiol. Isopentyldiol is a solvent suitable for dissolving various ingredients. Sandal Pentanol/Sandalore are likely oil-soluble fragrance or aroma chemicals which should dissolve in Isopentyldiol. This part is also feasible.
• Combining Part A and B: Since Isopentyldiol is water-soluble, Part B should readily mix into the aqueous Part A, forming a single phase.

The overall method is feasible, but requires careful execution, particularly regarding the dissolution of powders and precise pH adjustment after combining the parts to ensure stability and efficacy.

Ingredients and Their Functions

The formulation includes several ingredients known for their benefits in hair care:

• Isopentyldiol: Acts as a solvent and humectant, helping to dissolve other ingredients and provide moisture. The 5% concentration is within typical usage rates.
• Clover Flower Extract (Biochanin A 98%): An active ingredient known to help nourish hair and hair roots, reduce hair fall, and increase hair growth by inhibiting 5-alpha reductase and providing antioxidant benefits. The proposed 5% is significantly higher than the generally recommended 0.1-0.5%, which might offer enhanced effects but should be tested for solubility and potential irritation at this concentration.
• Sandal Pentanol (Sandalore): This is likely an aroma chemical used for its scent. Its function at 5% in a hair treatment, beyond fragrance, is not clear from the available information. High concentrations of fragrance materials can sometimes cause irritation.
• Minoxil Aqua™ (Diaminopyrimidine Oxide Water Soluble): An active ingredient that helps reduce hair loss, stimulate hair growth, and strengthen hair roots by working on the hair follicle structure. The 2% concentration is a common usage rate for such actives.
• Minoxol Aqua™ (Pyrrolidinyl Diaminopyrimidine Oxide Oxothiazolidinecarboxylate): Similar to Minoxil Aqua, this ingredient helps restore weak hair follicle cells, increase hair growth, and prevent hair loss. The 2% concentration is also within typical usage rates.
• Biotinyl-GHK (Biotinoyl Tripeptide-1): A peptide that helps accelerate hair growth by binding to hair proteins. The 3% concentration is the recommended usage rate for this ingredient.
• Hydrolyzed Keratin (Liquid, Deodorized): A protein that helps protect and restore damaged hair, improving strength, moisture, and shine. The 2% concentration is within the recommended range for rinse-off products and provides some benefit in leave-on products, although higher concentrations are often used for intensive repair.
• N-Acetyl Cysteine (Glutathione Precursor): An antioxidant that can help strengthen hair roots and reduce hair loss. It is a precursor for glutathione synthesis and is used in hair products for its strengthening properties. The 5% concentration is at the higher end of the recommended range (1-5%). Its acidic nature requires pH adjustment of the final product.
• Aqua: The primary solvent, forming the base of the water-based formulation.

Expected Results

Based on the combination of active ingredients, this formulation is expected to:

• Reduce hair loss: Ingredients like Clover Flower Extract, Minoxil Aqua, Minoxol Aqua, and N-Acetyl Cysteine are known to help combat hair shedding.
• Promote hair growth: Minoxil Aqua, Minoxol Aqua, and Biotinyl-GHK are specifically included for their ability to stimulate hair follicles and support the hair growth cycle.
• Strengthen hair: Hydrolyzed Keratin and N-Acetyl Cysteine contribute to improving the strength and resilience of the hair fiber.
• Improve scalp health: Ingredients targeting hair roots and follicles can also contribute to a healthier scalp environment.

The high concentration of multiple potent actives suggests this formula is designed for significant efficacy in addressing hair thinning and promoting density.

Considerations

• pH Management: The low pH of N-Acetyl Cysteine requires careful pH adjustment of the final product to be within the optimal range (3-6) for its stability and compatibility with other ingredients.
• Solubility at High Concentrations: While the solvents are appropriate, ensuring complete and stable dissolution of all ingredients, especially Clover Flower Extract and N-Acetyl Cysteine at 5%, should be verified through testing.
• Potential Irritation: The high concentration of multiple actives and potentially Sandal Pentanol could increase the risk of scalp irritation, especially for sensitive individuals.
• Sandal Pentanol/Sandalore Function: Clarifying the specific purpose and safety data for Sandal Pentanol/Sandalore at 5% is important, particularly if it is solely for fragrance.

In summary, the formulation is technically feasible with careful attention to mixing procedures and pH adjustment. It contains a powerful blend of ingredients targeting hair loss and promoting growth, and the expected results align with the known properties of these actives. However, thorough testing for stability, compatibility, and irritation potential is crucial before production.