Anti-Aging Serum Formulation for Oily, Acne-Prone Skin: Peptide Compatibility

Question

I am developing an anti-aging and firming serum formulation using an Aloe Vera Gel base, suitable for oily, acne-prone skin. My proposed active ingredients are:

Pep-Coll (Palmitoyl Tripeptide-5) - 3%
Matrixyl 3000 (Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7) - 5%
Vitamin B3
Japanese Cedar
Cell Energy
Repair Activator
Rosa Hybrid Cell
Caffeine
Hydrogenated Lecithin

My question is about the compatibility and effectiveness of using both Pep-Coll and Matrixyl 3000 together in the same formulation, and if the other ingredients and the Aloe Vera Gel base are suitable for the target skin type and benefits.

MySkinRecipes Expert · Accepted Answer

Thank you for sharing your formulation idea for an anti-aging and firming serum using Aloe Vera Gel base, suitable for oily, acne-prone skin.

Based on the ingredients you've selected and the feedback received:

The staff advises that Pep-Coll (Palmitoyl Tripeptide-5) and Matrixyl 3000 (Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7) have similar functions. Using both simultaneously will not significantly increase effectiveness. It is recommended to choose only one of these peptides for your formulation.
The other active ingredients you have chosen (Vitamin B3, Japanese Cedar, Cell Energy, Repair Activator, Rosa Hybrid Cell, Caffeine, Hydrogenated Lecithin) are considered suitable for your goals (anti-aging, firming) and skin type (ผิวมัน, เป็นสิวอุดตันง่าย).

Your selection of Aloe Vera Gel base is also appropriate for oily skin.

Overall, the formulation looks good, with the suggestion to select either Pep-Coll or Matrixyl 3000.