Best Solvent and Ratio for Dissolving Cetyl Tranexamate HCl (TXC™) in Eye Cream

To dissolve TXC™ (Cetyl Tranexamate HCl) efficiently for an eye cream formulation, the best solvents are specific glycols or esters. Since you prefer an oil-based option or the smallest amount possible, here are the recommendations:

Recommended Solvents

1. LipidSoft™ CC (Cetyl Ethylhexanoate): This is an excellent oil-based ester for eye creams because it is very light, non-greasy, and provides a smooth skin feel. It is highly effective at dissolving TXC™ when heated.
2. Butylene Glycol or Propylene Glycol: These are glycol-based solvents that are also very effective.

Required Amount for 300mg of TXC™

To achieve complete dissolution using the smallest amount of solvent, a ratio of approximately 1:4 or 1:5 (TXC™ to Solvent) is typically required, along with heat.

• For 300mg of TXC™: You will need approximately 1.2g to 1.5g of solvent (such as LipidSoft™ CC).

Dissolution Procedure

1. Mix 300mg of TXC™ with 1.2g - 1.5g of LipidSoft™ CC (or your chosen glycol).
2. Heat the mixture to 60-80°C.
3. Stir until the powder is completely dissolved and the liquid is clear.
4. Once dissolved, this mixture can be added to the oil phase of your eye cream formulation.

Note: TXC™ is not soluble in water. Always ensure the solvent and TXC™ mixture is clear before incorporating it into the rest of your formula. For an eye cream, using LipidSoft™ CC is ideal as it helps maintain a lightweight texture suitable for the delicate eye area.