Explanation for Gel Instability with Laurocapram

The issue you encountered with your Carbopol gel becoming unstable and forming white clumps after adding Laurocapram mixed with water and Propylene Glycol is likely due to the type of Laurocapram used. Laurocapram comes in both oil-soluble and water-soluble forms.

Carbopol gels are water-based systems. If you used the Laurocapram (Oil Soluble) type, it would not be compatible with the water-based gel, causing it to separate and destabilize the gel structure, resulting in the white clumps you observed.

Correct Usage

• If you are working with a water-based gel like Carbopol, you should use Laurocapram (Water Soluble).
• Laurocapram (Water Soluble) should be mixed into the water phase of your formulation before adding the gelling agent (Carbopol) or before neutralizing the Carbopol to form the gel.
• Laurocapram (Oil Soluble) is intended to be mixed into the oil phase of a formulation.

Alternative Penetration Enhancers

If you need alternative penetration enhancers suitable for a water-based gel, consider the following options:

• Laurocapram (Water Soluble): As mentioned, this is the water-soluble version and is suitable for water-based systems.
• Phospholipid: Some types are water-dispersible or water-soluble and can help enhance penetration while also providing skin benefits.
• 1,2-Hexanediol: Can be used in combination with other carriers to enhance penetration and also acts as a preservative and humectant.
• Ethoxydiglycol: A good solvent and penetration enhancer for water-based formulas.
• Dimethyl Isosorbide (DMI): A widely used and effective penetration enhancer for water-based systems.

Ensure that any penetration enhancer you choose is compatible with your specific gel system and other ingredients.