Cold Process Cream Formulation with Acne-Fighting Ingredients

Creating a stable, thick cream formulation using a cold process with the ingredients you've specified, particularly AcnePLEX™ and MicroKill™ (Quaternium-73), presents a compatibility challenge.

Both AcnePLEX™ and MicroKill™ carry positive charges. Many common cold-process cream makers and thickeners are anionic (negatively charged). Mixing positively charged ingredients with negatively charged polymers typically leads to instability, such as separation or loss of viscosity.

While we searched for cold-process cream makers and non-ionic options, the results showed limitations:

• Some cold-process options found (like Easy Cream Maker™, CreamMaker EG™, Velvet Cream Maker™) are anionic or likely incompatible with positively charged ingredients.
• Non-ionic cream makers identified (such as Soft Cream Maker™ and SureCream™) require heat (60-80°C) to form a stable emulsion, which conflicts with your cold-process requirement.

The documentation for AcnePLEX™ specifically recommends using non-ionic gel makers (like HEC or HPMC) to achieve viscosity in formulas containing it, due to its positive charge and potential incompatibility with charged thickeners/emulsifiers. This suggests that achieving a thick cream texture via a cold process using a compatible emulsifier is difficult or not possible with typical available ingredients that meet all constraints.

Given the need for a cold process and the presence of positively charged ingredients, the most stable approach for viscosity would likely result in a gel or gel-cream texture using a non-ionic thickener compatible with positive charges.

If a thick cream texture is essential, you might need to consider using a non-ionic emulsifier that requires heat, such as SureCream™, which would mean adjusting your process to include a heating step.