Combining Activated Resorcinol and Tranexamic Acid for Melasma

Yes, Activated Resorcinol (4-Butyl Resorcinol) and Tranexamic Acid can generally be used together in cosmetic formulations to target melasma and hyperpigmentation. Both ingredients work through different mechanisms to reduce melanin production, potentially offering enhanced results when combined.

How long to see results?

Based on studies for Activated Resorcinol, you can typically expect to start seeing results in reducing pigmentation and melasma after at least 4 weeks of consistent use, especially at a 1% concentration. However, individual results may vary depending on skin type, severity of melasma, and overall formulation.

Formulation Considerations and Example

When combining these ingredients, careful formulation is necessary to ensure stability and efficacy. Activated Resorcinol is oil-soluble and prefers a pH range of 4.5-5.5, while Tranexamic Acid is water-soluble and stable in a wider pH range (3-8).

Here is an example cream recipe using 1% Activated Resorcinol, which can be adapted to include Tranexamic Acid:

• Activated Resorcinol: 1%
• Water: 92.8%
• LipidSoft (or any oil): 5%
• Light Cream Maker: 1%
• Pro Polymer or AnyGel: 0.5% (for stability)
• Disodium EDTA: 0.2% (helps prevent discoloration of Activated Resorcinol)
• ActiveProtec™ OX: 0.6% (recommended to prevent discoloration)

Mixing Steps:

1. Melt Activated Resorcinol in the oil phase (LipidSoft). Add Light Cream Maker to the oil phase and stir well.
2. Add Pro Polymer or AnyGel to the water phase and blend until gel-like. Add Disodium EDTA to the water phase and blend until dissolved.
3. Gradually add the water phase to the oil phase while blending or stirring well.
4. Add ActiveProtec™ OX.

To incorporate Tranexamic Acid (up to 3% for cosmetic use), it should be dissolved in the water phase before combining with the oil phase. Ensure the final pH of the formula is within the optimal range for both ingredients (ideally around pH 4.5-5.5).

Consider using the encapsulated or nano versions like NanoRes™ (Liposome 4-Butyl Resorcinol) or Nano-TXA™ (Tranexamic Acid Nano Emulsion) as they are water-soluble and designed for improved stability and skin penetration, which can simplify formulation.

Remember to always use sun protection (SPF 30 or higher) daily when using whitening ingredients to prevent further pigmentation and protect your skin.