Combining Active Ingredients and Choosing Anti-Irritants for Spot Corrector

Hello,

Regarding your questions about using Ethyl Ascorbic Acid, Tranexamic Acid, and Azelaic Acid for a spot corrector targeting melasma and dark spots, here is a summary of the information provided by the staff:

Suitable Time for Use:

• Ethyl Ascorbic Acid and other Vitamin C derivatives: Can be used both day and night.
• Tranexamic Acid: Can be used both day and night.
• Azelaic Acid: Due to its exfoliating properties, it is recommended for nighttime use only.

Combining Ingredients:

• Ethyl Ascorbic Acid can be combined with other ingredients, except for Safe-B3 (Niacinamide).
• Tranexamic Acid and Azelaic Acid are ingredients that may cause irritation. If you wish to use them together in the same formula, the concentration of each should be reduced.
• Regarding the formulations you proposed:
  • Daytime: Ethyl Ascorbic acid 3% + Tranexamic Acid 3%
  • Nighttime: Ethyl Ascorbic acid 3% + Azelaic Acid 10%
    
    The staff confirmed that these formulations are possible.

Product Texture (Gel vs. Cream):

• This question has been forwarded to user C7 for further advice.

Choosing Anti-Irritant Ingredients:

• You are considering four anti-irritant ingredients: Allantoin, Creatine 100, Bisabolol, and Calendula Extract.
• The staff advises that using a variety of ingredients at lower proportions is often more effective than using a single ingredient at a high concentration.
• If incorporating multiple ingredients does not overly complicate the mixing process, the staff suggests considering adding all four anti-irritant ingredients at appropriate concentrations.
• Comparing Bisabolol and Calendula Extract (the water-soluble type available from the company), the staff indicated that Bisabolol provides better efficacy. This is because the water-soluble Calendula Extract available lacks some oil-soluble components that offer higher efficacy.

We hope this information is helpful.